GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs7927771 | 1 | rs11039412 | chr11:47841581 | C1QTNF4 | chr11:47611216-47615961:- | -0.3 | -5.58 | 4.54E-8 | Subjective well-being |
| BLCA | cis | rs7927771 | 1 | rs11039426 | chr11:47863119 | C1QTNF4 | chr11:47611216-47615961:- | -0.3 | -5.6 | 4.09E-8 | Subjective well-being |
| BLCA | cis | rs11051970 | 1 | rs11051970 | chr12:32537488 | FGD4 | chr12:32638906-32798982:+ | -0.34 | -5.39 | 1.27E-7 | Response to tocilizumab in rheumatoid arthritis |
| BLCA | cis | rs1105881 | 1 | rs1105881 | chr15:42072530 | SPTBN5 | chr15:42140345-42186275:- | 0.25 | 4.21 | 3.2E-5 | Educational attainment |
| BLCA | cis | rs17030613 | 1 | rs1106287 | chr1:113242122 | ST7L | chr1:113066142-113162405:- | 0.44 | 6.47 | 3.03E-10 | Diastolic blood pressure;Blood pressure |
| BLCA | cis | rs11064881 | 1 | rs11064881 | chr12:120146925 | PRKAB1 | chr12:120105757-120119428:+ | -0.67 | -6.59 | 1.48E-10 | Ulcerative colitis;Inflammatory bowel disease |
| BLCA | cis | rs2404602 | 1 | rs11072603 | chr15:76881138 | SCAPER | chr15:76640529-77197744:- | -0.21 | -4.64 | 4.69E-6 | Blood metabolite levels |
| BLCA | cis | rs4494548 | 1 | rs11074454 | chr16:20390151 | C16orf88 | chr16:19717676-19729492:- | -0.37 | -4.05 | 6.11E-5 | Urinary uromodulin levels |
| BLCA | cis | rs7224737 | 1 | rs11079034 | chr17:40288890 | DHX58 | chr17:40253422-40264751:- | -0.25 | -4.56 | 6.85E-6 | Fibrinogen levels |
| BLCA | cis | rs11084786 | 1 | rs11084785 | chr19:35282054 | ZNF181 | chr19:35225151-35233774:+ | -0.27 | -5.4 | 1.17E-7 | Urate levels (BMI interaction) |
| BLCA | cis | rs11084786 | 1 | rs11084786 | chr19:35282181 | ZNF181 | chr19:35225151-35233774:+ | -0.26 | -5.34 | 1.6E-7 | Urate levels (BMI interaction) |
| BLCA | cis | rs12608504 | 1 | rs11086102 | chr19:18398628 | KIAA1683 | chr19:18367906-18385319:- | -0.23 | -4.23 | 2.91E-5 | Waist-to-hip ratio adjusted for body mass index |
| BLCA | cis | rs11088226 | 1 | rs11088226 | chr21:33925531 | TCP10L | chr21:33947152-33957845:- | -0.34 | -4.54 | 7.57E-6 | Gastritis |
| BLCA | cis | rs1109114 | 1 | rs1109114 | chr5:148615946 | AFAP1L1 | chr5:148651401-148721365:+ | 0.26 | 4.7 | 3.65E-6 | Body mass index |
| BLCA | cis | rs9876781 | 1 | rs1109227 | chr3:48479207 | TREX1 | chr3:48501186-48509043:+ | -0.19 | -3.86 | 0.000134 | Longevity |